AML18 trial: How should gemtuzumab ozogamicin be applied in AML?

During the 25th Congress of the European Hematology Association (EHA), the AML Hub spoke to Nigel Russell, Guy's and St Thomas' NHS Foundation Trust, London, UK. We asked: How should gemtuzumab ozogamicin be applied in AML?

Here, Nigel Russell discusses the treatment of elderly patients with AML with the CD33-targeted antibody–drug conjugate, gemtuzumab ozogamicin, as part of the AML18 trial. The overall survival and response rates demonstrated by patients, who were randomized to receive either a single dose or a fractionated dosing schedule of gemtuzumab ozogamicin, are outlined.