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Patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) may receive transplants from either human-leukocyte-antigen identical (HLA-id) sibling donors, unrelated donors (UDs) or HLA-mismatched (Haplo) family donors. In the R/R AML patient population, allo-HSCT may allow patients to achieve a complete response (CR), with long-term control achieved through other immunomodulatory strategies. Since HLA-id sibling donors are only available in approximately 30% of cases; and unrelated donors (UD) take time to locate, transplants from Haplo donors have increased.1
Giorgia Battipaglia of Hôpital Saint Antoine, Paris, and Federico II University, Italy, and colleagues conducted a retrospective study comparing the outcomes of a large cohort of patients with R/R AML receiving HLA-id or Haplo HSCTs, utilizing the European Society of Blood and Marrow Transplantation (EBMT) Acute Leukemia Working Party (ALWP) registry.2
All results are given as Haplo versus HLA-id
Inferior outcomes were observed with the Haplo-HSCT group in terms of LFS, OS, NRM compared with HLA-id sibling transplants and the engraftment rate was higher in the HLA-id group. The primary cause of mortality in both groups was disease progression, followed by infections, which were more frequent in the Haplo recipients. Another factor shown to contribute to poorer outcomes was transplanting patients with relapsing disease when compared to those with refractory AML.
There was no exhibited difference in the rates of aGvHD or cGvHD when comparing donor type; however using ATG as GvHD prophylaxis conferred a poorer outcome. This is compared to using PTCy as prophylaxis to GvHD in Haplo HSCTs, which showed no difference when compared to HLA-id HSCTs indicating that this regimen may provide similar outcomes to HLA-id sibling transplants.
The time-critical element of finding a suitable donor for patients with R/R AML means that utilizing a readily available Haplo donor should be considered where a HLA-id donor is not available, especially considering the difficulty of locating UDs in certain ethnicities. This has only become feasible in recent years through improvements in conditioning regimens, immunosuppressive strategies and supportive care. However, whilst HSCTs from Haplo family-matched donors represent a viable alternative option when HLA-id sibling matches are unavailable, HLA-matched siblings are the ideal donors.
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