The mechanism of action of Arsenic Trioxide (ATO) has not been fully elucidated. However, Kamran Alimoghaddam1 has reported that ATO has induced differentiation in the NB4 cell line. In addition, the TRISENOX® summary of product characteristics states that ATO also causes damage or degradation of the fusion protein Pro-Myelocytic Leukemia/Retinoic Acid Receptor-α (PML/RAR-α).2
- Alimoghaddam K. A Review of Arsenic Trioxide and Acute Promyelocytic Leukemia. Int J Hematol Oncol Stem Cell Res. 2014 Jul 1; 8(3): 44–54.
- TRISENOX® Summary of Product Characteristics. https://www.medicines.org.uk/emc/medicine/28860. [Accessed January 2017].